JOSEP CARRERAS LEUKAEMIA FOUNDATION
21st Josep Carreras Gala in Germany: more resources to fight against leukaemia
The 21st Josep Carreras Gala,televised on the SAT.1 Gold channel, was held in Berlin on 17 December and this year it succeeded in raising 3.189.029 euros. Performing at the Gala were David Garrett, Al Bano & Romina Power and Die Prinzen, amongst other artists. Over the last twenty years these televised Christmas Galas have managed to raise over 200 million euros (more than 1.000 projects), a sum that has been entirely devoted to scientific research and to the establishment and improvement of facilities aimed at improving patients' quality of life. + info at: https://www.carreras-stiftung.de/
I want to thank you…
How important it is to say THANKYOU! We will never tire of doing so because, with your unconditional support, you have helped us on our way to achieving our aim: to make leukaemia and other malignant blood diseases 100% curable. This Christmas, if you too would like to say thankyou to those you love, you can sent an interactive Foundation card via Facebook. The app is simple and free. You can find it here: http://www.quierodartelasgracias.com/
JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE
The Stem Cell, Mesenchymal Cancer and Development Group at the University of Barcelona Hospital Clínic Campus has published a revision article on infantile acute lymphoblastic leukaemia t (4; 11) / MLL-AF4 + B in Blood. This particular article, under the direction of Dr. Sanjuan-Pla, focuses on what is known about this form of leukaemia, some of the particular characteristics of studying a disease that appears in such young patients, and goes on to mention what the group hopes will be the result of the application of new technologies in this field of research. + info
World experts on infantile lymphoblastic leukaemia t (4; 11) / MLL-AF4 + B
It is a great honour for our Institute for the Stem Cell, Mesenchymal Cancer and Development Group at the University of Barcelona Hospital Clínic Campus of the IJC to have been invited to contribute this article to the journal Blood since it highlights our researchers as world leaders in the study of this disease. In fact, the members of Dr. Menéndez's research group have been invited to form part of the international consortium to study patients with this acute leukaemia with translocation of the MLL gene. At the present time it is the only Spanish research centre to form part of this consortium. Similarly, the members of the IJC toxicology and environmental work group, who are researching into paediatric leukaemia and investigating the idea that the disease might be caused by toxic exposure, have been named AD HOC experts by the European Food and Safety Authority (EFSA).
New paper published in Leukemia
The scientific journal Leukemia recently published the first paper to demonstrate that mature blood and umbilical cord B cells, both of which have a very defined function, can be reprogrammed to become pluripotent stem cells. These immature cells have the ability to differentiate into other cell types with multiple functions. For years researchers around the world have been trying to extract a conclusion from this, the prevailing idea being that lymphocyte B cells, the blood cells responsible for the formation of defences or antibodies, as opposed to T cells or myeloid cells, could not be reprogrammed through genetic rearrangement. In 2012 the Nobel Prize for Medicine was awarded to Shinya Yamanaka and Sir John B. Gurdon for their research into the phenomenon of reprogramming which was achieved using two improved techniques: 1) expression of the CEBPa gene that induces B cells to become myeloid cells, which is to say that some cells can acquire the functions of other cells, and 2) through the use of the sendai virus, which simultaneously expresses the four reprogramming genes needed to form stem cells from other cells with a very defined function. These stem cells, induced from lymphocyte B cells, will be useful in understanding B lymphocyte physiology and also for understanding B lymphocyte leukaemias better.
REDMO participates in a course on the transplant of hematopoietic precursors in Malaga
A course on the transplant of hematopoietic precursors was held in Malaga on 18 and 19 November. The course was organised by the Autonomous Transplant Coordination of Andalusia under the direction of Manuel Alonso Gil, the Autonomous Transplant Coordinator of Andalusia and Antonia Álvarez Márquez, the Autonomous Transplant Coordination of Andalusia Technical Assistant.
Dr. Carreras gave a paper in which he explained how the Bone Marrow Donor Registry (REDMO) went about its task of searching for and selecting non-related donors. Those attending the course were hematologists who are not directly involved in bone marrow transplants and it enabled them to learn more about this procedure and to clarify any doubts they might have had about the transplant of hematopoietic precursors, to the general benefit of their professional practice.
In Andalusia, when the course was held, there were 40,073 registered donors and in 2014 the five Hematopoietic Precursors Transplant Centres of the Autonomous Community of Andalusia performed 79 transplants.
REDMO participates in the World Marrow Donor Association Congress and at the American Registry Annual Congress
As already reported, Mario Gran, Cristina Fusté and Núria Marieges represented the Bone Marrow Donor Registry in Minneapolis at the two consecutive congresses held every autumn in the capital of the state of Minnesota, the biannual World Marrow Donor Association and the annual congress of the American Registry. With regard to the selection of donors, one of the most interesting things our representatives have reported from the meetings is the emergence of the new DPB1 locus. This is a very variable locus and is consequently very difficult to predict. It will, furthermore, undoubtedly make the search process more complicated.
In this regard, the suggestion has been made to the country's experts in the field that, if they consider it to be appropriate, the current immunological document establishing the search strategy employed by REDMO be modified.
Another important technical change being discussed is the implementation of a single donor code format, called GRID, for all registers. Based on the international ISBT code, this modification would ensure the traceability of donors throughout the entire process.
5th Michelin Stars dinner
On 6 November the Palau del Baró restaurant, the Lliga Contra el Càncer de Tarragona (Tarragona against cancer league) and the Ebre districts organised a fund-raising dinner which consisted of a tasting menu, prepared by a number of chefs distinguished by their Michelin stars, together with well-known restaurateurs in Tarragona. The event took place at the Antiga Universitat Laboral de Tarragona.
All the ingredients for the meals were donated by the MAKRO company and there was a fund-raising raffle of products donated by local business people. Over the last five years these dinners have raised over €7,000!
Run with Javito!
On 6 December one of our collaborators ran the Malaga Marathon, 42 km 195 m in all. His intention was to try and complete the course in less than 3 hours 15 minutes, and he managed to do it! To raise funds with his efforts he created a challenge through the www.migranodearena.org platform where he asked people to collaborate with every euro giving him the strength for the next 5 metres.
As well as proudly achieving his aim he managed to raise €5,675.14! We will continue covering the kilometres on our road ahead, the road leading to the definitive cure for leukaemia!
Sant Hilari Sacalm musters its forces against leukaemia!
Anna Villacrosa is from Sant Hilari Sacalm (Girona) and at present she is admitted as a patient suffering from leukaemia at Hospital Clínic in Barcelona awaiting a bone marrow transplant. Her enormous enthusiasm for contributing towards the fight against leukaemia led her to organise a fund-raising day involving the people of Sant Hilari Sacalm with the support of the local town council.
There was dancing, theatre and song as well as an awareness-raising video in which various famous people lent their support to those patients immersed in the fight against a cancerous blood disease. (you can see the video here).
More than 800 people took part in the event which raised €7,259. Sant Hilari Sacalm, unstoppable in the fight against leukaemia!