New advances in acute lymphoblastic leukaemia in adults
-RELAPSES IN T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA IN ADULTS: On the other hand, Dr Eulalia Genescà and Dr Josep Maria Ribera have worked together on the study, published in the Genome Biology journal, with the laboratory of Núria López-Bigas at IRB Barcelona and with Anna Bigas’ groups at the Hospital del Mar Medical Research Institute.
It is a genetic study of a type of acute lymphoblastic leukaemia, the T-cell type, which despite initially responding to treatment positively, has frequent relapses and a bad prognosis.
The group has studied how these patients were genetically upon diagnosis and at the time of relapse. The team has discovered that the cells responsible for resistance to treatment of T-ALL leukaemia in adults are already present in the tumours before the first diagnosis.
To carry out this work, they have sequenced the genome of samples from 19 patients at the time of diagnosis as well as during treatment and upon relapse, and they have compared the information obtained with a database of 238 patients (adults and children) affected by similar tumours. Through the comparison of the primary leukaemias of the adults and those of the paediatric patients, they could observe that the mutational processes are similar, although the specific genetic alterations responsible for the relapse are different in each individual case. For this reason, an algorithm is being developed to classify these relapses, as not all of them are the same. Sometimes the patient can relapse from the same disease they initially had, and other times it is seen that upon relapse the leukaemia has changed.
This has permitted in-depth study of the matter of relapses and their complexity. Almost every relapse is different, which has major implications for designing the treatment. For this reason, the team will continue to be UNSTOPPABLE to continue getting to know them in more detail.