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Bone marrow failure

Bone marrow failure includes a heterogeneous group of diseases characterised by the failure of the hematopoietic function (blood production), leading to the inappropriate production of red blood cells, white blood cells and platelets.

Bone marrow failures can be quantitative (on account of a decrease in the number), or qualitative (on account of producing anomalous cells:  bone marrow dysplasia) and can affect one, two or all three hematopoietic cell lines, giving rise to mono-, bi-, or pancytopenia, respectively.   

Series affected Denomination Series affected Denomination Congenital or constitutional Acquired Series affected Denomination Congenital or constitutional Acquired
Roed Erythroblastopenia Diamond- Blackfan syndrome Pure red cell aplasia
White

Neutropenia

Kostmann syndrome

Reticular dysgenesis

Schwachman-Diamond syndrome

Idiopathic

Medicamentosa
Platelet

Thrombocytopenia 

Amegakaryocytic ± absent radii

Idiopathic

Medicamentosa
All Global bone marrow failure

Fanconi anemia

Congenital dyskeratosis
Acquired bone marrow aplasia
Webpage updated 02/13/2020 16:48:59