Bone marrow failure
Bone marrow failure includes a heterogeneous group of diseases characterised by the failure of the hematopoietic function (blood production), leading to the inappropriate production of red blood cells, white blood cells and platelets.
Bone marrow failures can be quantitative (on account of a decrease in the number), or qualitative (on account of producing anomalous cells: bone marrow dysplasia) and can affect one, two or all three hematopoietic cell lines, giving rise to mono-, bi-, or pancytopenia, respectively.
| Series affected | Denomination | Series affected Denomination Congenital or constitutional Acquired | Series affected Denomination Congenital or constitutional Acquired |
|---|---|---|---|
| Roed | Erythroblastopenia | Diamond- Blackfan syndrome | Pure red cell aplasia |
| White |
Neutropenia |
Kostmann syndrome Reticular dysgenesis Schwachman-Diamond syndrome |
Idiopathic Medicamentosa |
| Platelet |
Thrombocytopenia |
Amegakaryocytic ± absent radii |
Idiopathic Medicamentosa |
| All | Global bone marrow failure | Congenital dyskeratosis | Acquired bone marrow aplasia |
